NucPred Predicting nuclear localization of proteins
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چکیده
منابع مشابه
NucPred - Predicting nuclear localization of proteins
UNLABELLED NucPred analyzes patterns in eukaryotic protein sequences and predicts if a protein spends at least some time in the nucleus or no time at all. Subcellular location of proteins represents functional information, which is important for understanding protein interactions, for the diagnosis of human diseases and for drug discovery. NucPred is a novel web tool based on regular expression...
متن کاملPredicting nuclear localization.
Nuclear localization of proteins is a crucial element in the dynamic life of the cell. It is complicated by the massive diversity of targeting signals and the existence of proteins that shuttle between the nucleus and cytoplasm. Nevertheless, a majority of subcellular localization tools that predict nuclear proteins have been developed without involving dual localized proteins in the data sets....
متن کاملPredicting the Nuclear Localization Signals of 107 Types of HPV L1 Proteins by Bioinformatic Analysis
In this study, 107 types of human papillomavirus (HPV) L1 protein sequences were obtained from available databases, and the nuclear localization signals (NLSs) of these HPV L1 proteins were analyzed and predicted by bioinformatic analysis. Out of the 107 types, the NLSs of 39 types were predicted by PredictNLS software (35 types of bipartite NLSs and 4 types of monopartite NLSs). The NLSs of th...
متن کاملDimerization and nuclear localization of ku proteins.
Ku, a heterodimer of Ku70 and Ku80, plays a key role in multiple nuclear processes, e.g. DNA repair, chromosome maintenance, and transcription regulation. Heterodimerization is essential for Ku-dependent DNA repair in vivo, although its role is poorly understood. Some lines of evidence suggest that heterodimerization is required for the stabilization of Ku70 and Ku80. Here we show that the hete...
متن کاملYeast proteins that recognize nuclear localization sequences
A variety of peptides can mediate the localization of proteins to the nucleus. We have identified yeast proteins of 70 and 59 kD that bind to nuclear localization peptides of SV-40 T antigen, Xenopus nucleoplasmin, and the yeast proteins Ga14 and histone H2B. These proteins are assayed by the binding of peptide-albumin conjugates to proteins immobilized on nitrocellulose filters. These binding ...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2007
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btm066